Objective: To optimize molding process of Tangshenning granules. Method: With moldability

dissolubility

hygroscopicity and post-moisture absorption appearance as comprehensive indexes

single factor test was conducted to determine excipient types

central composite design-response surface methodology was adopted to optimize excipient ratio

dosage

wetting agent concentration and other molding process parameters. Result: According to optimal molding process

ratio of extract-dextrin-mannitol was 4 : 3 : 3

75% ethanol was added as softening materials

drying temperature was at 55 ℃.Average value of overall desirability (OD) was 0.786

its deviation from the theoretical prediction value (0.78) of the model equation was about 0.8%.Yield of qualified granules was about 88.44%

melting time was less than 0.5 min

critical relative humidity was about 70%

angle of repose was 34.8 degrees

and bulk density was 0.49 g · mL-1. Conclusion: This optimized molding process is stable and feasible with a high qualified rate

good dissolubility and high anti-hygroscopicity for these prepared Tangshenning granules

and it can provide basis for mass production of this preparation.