Objective: To investigate the anti-inflammatory and analgesic effect of essential oil from Chrysanthemi Indici Flos (EOCIF). Method: Totally 60 KM mice were divided into six groups

i.e. the normal group

the model group

the aspirin group (0.5 g · kg-1)

EOCIF high

middle and low dose groups (0.8

0.4

0.2 g · kg-1). Auricle edema induced by dimethylbenzene

cotton pellet granuloma of the mice and foot edema induced by carrageen were used to detect the anti-inflammatory activity. Acetic acid writhing method and hot-plate method were used to study the analgesic activity. Result: Compared with the normal group

the model group showed notable auricle edema and cotton pellet granuloma and significant increase in writhing frequency

with significant statistical difference (P <0.05). Compared with the model group

EOCIF high

middle and low dose groups showed obvious inhibitory effects in dimethylbenzene-induced auricle edema

cotton pellet granuloma and carrageen-induced foot edema and significant decrease in writhing frequency

with significant statistical difference (P <0.05). Besides

after the administration

compared with the model group

EOCIF high

middle and low dose groups showed obvious increase in pain threshold in mice (P <0.05). Conclusion: The EOCIF Chrysanthemi Indici Flos shows stronger anti-inflammatory and analgesic activities.