Objective: To observe the effect of Danhong injection in relieving blood stasis and thrombosis of patients with chronic renal failure (CRF) maintenance hemodialysis. Method: Totally 130 patients with CRF maintenance hemodialysis were divided into the observation group (65 cases) and the control group (65 cases) by the random numbers table method. Patients in the control group took Dipyridamole tablets

50 mg/time

3 times/day for continuing administration. In addition to the therapy of the control group

patients in the observation group was given 30 mL Danhong injection and 100 mL 0.9% saline solution for slow intravenous dripping

1 times/day. One treatment course was ten days

once a month. The total course lasted for 3 months. The blood stasis syndrome was scored at the first

second and third months before and after the treatment. The changes in blood rheology indexes

fibrinogen (FIB) level

D-dimmer (D-D)

platelet granule membrane protein (CD62 P)

lysosomes platelet granule membrane protein (CD63)

thrombin sensitive protein (TSP)

thromboxane (TXB2)

6-Ketone-prostaglandin F1α(6-Keto-PGF1α) were detected before and after the treatment. Result: The blood stasis syndrome scores in the observation group were lower than that in the control group at the second and third months after the treatment (P <0.01). The blood stasis syndrome score in the observation group declined faster than that in the control group at the second and third months after the treatment (P <0.01). After the treatment

the whole blood viscosity (high

low)

plasma viscosity and platelet aggregation rate in the observation group were higher than that in the control group (P <0.01). The levels of TXB2

FIB and D-D in the observation group were lower than that in the control group (P <0.01)

but with higher 6-Keto-PGF1α than that in the control group (P <0.01). The CD62 P and TSP in the observation group were less than that in the control group (P <0.05)

with no statistical significance in differences in CD63 between both groups. Conclusion: Danhong injection can relieve blood stasis among patients with chronic renal failure maintenance hemodialysis

inhibit platelet activation

enhance microcirculation

reduce high blood coagulation state

and prevent the thrombosis.