Objective: To systematically evaluate the efficacy and safety of sodium ozagrel combined with Dengzhan Xixin preparations in treating cerebral infarction (CI). Method: Randomized controlled trails (RCT) about sodium ozagrel combined with Dengzhan Xixin preparations in the treatment of CI were collected by retrieving from PubMed

EMbase

Cochrane Library

FMJS

CNKI

VIP and Wanfang database. The methodological quality of the included studies was evaluated

and a Meta-analysis was made for them by Rev Man 5.3.4 statistical software. Result: A total of 22 RCT were included

involving 2 198 patients. The results of Meta-analysis showed that sodium ozagrel combined with Dengzhan Xixin preparations could significantly improve the total effective rate [OR＝3.76

95% CI (2.84

4.97)

P< 0.000 01]

obvious effective rate [OR＝2.07

95% CI (1.71

2.49)

P< 0.000 01] and neurological deficit scores [MD＝-5.08

95% CI (-5.73

-3.53)

P< 0.000 01]

with statistical significance in their differences. Conclusion: Sodium ozagrel combined with Dengzhan Xixin preparations is efficient in the treatment of CI

with no significant adverse reaction. However

restricted by the low methodological quality of the trials enrolled in the study

its efficacy shall be further confirmed by a high-quality RCT.