Objective: To observe the effect of Tongfengan liquid (TFAL) on hyperuricemia mice. Method: Totally 115 SPF-grade KM mice were divided into the blank group (the same volume of distilled water)

the model group (the same volume of distilled water)

the allopurinol group (40 mg·kg-1)

the colchicine tablets group (0.25 mg·kg-1) and TFAL low

medium and high doses groups (8.45

16.9

33.8 g·kg-1)

with 15 mice in each group. They were orally administered with drugs for 28 days. One hour after the last administration

the serum uric acid level

creatinine (Cr)

urea nitrogen (BUN)

interleukin-6(IL-6)

tumor necrosis factor-α(TNF-α) contents and xanthine oxidase (XOD) activity levels were detected. Result: Compared with the normal group

the model group showed significant increases in hyperuricemia level

XOD activity and contents of Cr

BUN

IL-6 and TNF-α (P<0.01). Compared with the model group

the level of uric acid

XOD activity and contents of Cr

BUN

IL-6 and TNF-α in each TFAL group were significantly lower (P<0.01). Conclusion: TFAL has therapeutic and protective effects on hperuncemia mice.