Objective: To explore the effect of Astragali Mongolici Radix and its active ingredient Astragali Mongolici Radix polysaccharideits on the expressions of homocysteine(Hcy)

nuclear factor(NF-κB) and D-dimer(D-D) in heart failure model mice. Method: Totally 100 SPF male mice were divided into the normal group (20 mice) and the model group (80 mice) by random. The heart failure mice model was induced through the intraperitoneal injection with isoproterenol. After the successful modeling

they were randomly divided into the RA group (Astragali Mongolici Radix

3 g·kg-1)

the APS group (Astragali Mongolici Radix polysaccharideits

3 g·kg-1)

the positive medicine group (Digoxin

0.05 mg·kg-1) and the model group

with 20 mice in each group. The RA group was orally given 3 mL·kg-1·d-1 Astragali Mongolici Radix extract liquid (1 g·mL-1);the APS group was intraperitoneally injected with 3 mL·kg-1·d-1 of Astragali Mongolici Radix polysaccharide;the positive drug group was orally given 0.05 mL·kg-1·d-1 of digoxin;the model control group was orally given 3 mL·kg-1·d-1 of sterile saline. All of them were treated for 4 weeks. After the experiment

their apex cordis and myocardial tissues were collected for pathological examination. The blood was drawn from abdominal arteries for detecting the expressions of Hcy

NF-κB and D-D. Result: The expressions of Hcy

NF-κB and D-D in the model group were higher than that of the normal group (P<0.05). According to the pathological results

the model group showed less myocardial fiber

lighter staining

vague bands and partial replacement of necrotic lesions with scar tissues. Compared with the model group

all of treatment groups showed obvious reductions in Hcy

NF-κB and D-D levels (P<0.05). The pathological results also showed significant reduction in necrotic lesions in apex cordis and myocardial tissues in all of treatment groups. Compared with the RA group and the Digoxin group

the APS showed more significant effects. Conclusion: Astragali Mongolici Radix and its active ingredient APS could obviously reduce the expressions of Hcy

NF-κB and D-D in mice with heart failure;but the latter drug has a better effect than the former.