Objective: To investigate the efficacy of Jiawei Suanzaoren decoction combined with eszopiclone in treating anxiety insomnia and its effects on level on 5-hydroxytryptamine (5-HT) and dopamine (DA). Method: Totally one hundred and twenty cases of anxiety insomnia were randomly divided into two groups by the random number table

the control group and the observation group

with 60 cases in each group. The control group was treated with eszopiclone

while the observation group was treated with Jiawei Suanzaoren decoction combined with eszopiclone. The curative efficacy of anxiety insomnia

scores of manifest anxiety scale

serum 5-HT

DA and adverse reactions were observed and compared. Result: The observation group showed a total therapeutic efficiency ratio of 95.0%

which was significantly higher than that of 81.7% in the control group (P<0.05). In comparison with the control group

score of SAS

HAMA

5-HT

DA substantially increased

with statistical differences (all P<0.05). As for the adverse reactions

incidence of bitter taste in mouth and sleepiness in the observation group was statistically lower than that in the control group (all P<0.05)

with no statistical difference in incidences of nausea

constipation and dizziness between the two groups. Conclusion: Jiawei Suanzaoren decoction combined with eszopiclone in treating anxiety insomnia has a reliable efficacy

which can significantly increase the curative efficacy

alleviate anxiety emotion and regulate level of neurotransmitter

with lower incidence of adverse reactions. It is worth further studies in clinic.