Objective: To study the clinical effect of Shengui Yixin decoction on patients with chronic heart failure and its effect on cardiac ultrasound index. Method: Totally one hundred and twenty-four cases of heart failure patients were divided randomly into the control group (n=50) and the treatment group (n=74) according to the odevity of their admission time. The control group received the therapies of removing inducing factors

adjusting lifestyle

providing psychological intervention for those with anxiety and depression and taking drugs

including diuretics

angiotensin converting enzyme inhibitors(ACEI) drugs

beta blockers

aldosterone receptor antagonist

angiotensin receptor antagorists(ARB)

digoxin. The treatment group was given Shengui Yixin decoction for 4 weeks

4 tablets/time

3 times/day

with 2 weeks in 1 courses of treatment

in addition to the therapies of the control group. The therapeutic effect was evaluated by Lee's heart failure score

the N terminus natriuretic peptide (NT-proBNP)

cardiac troponin (cTn) and galectin-3 were observed. The life quality was evaluated by the 36-item short form health questionnaire (SF-36) and the Minnesota living with heart failure quality scale (MLHFQ). The patients' cardiac output (CO)

stroke volume (SV)

left ventricular ejection fraction (LVEF)

left ventricular end diastolic diameterleft (LVDD) and cardiac index (CI) were detected by ultrasound. Result: After the four-week treatment

the efficacy of the treatment group was significant statistically compared with the control group (P<0.05). The total effective rate of the treatment group was significant statistically compared with the control group (P<0.05). NT-proBNP

cTn

galectin-3 and Lee score in the control group were significant statistically compared with that before the treatment (P<0.05). NT-proBNP

cTn

galectin-3 and Lee's score in the treatment group after the treatment were significant statistically compared with the control group before the treatment (P<0.05). SV

CO

LVEF

LVDD

CI in the control group were significant statistically compared with that before the treatment (P<0.05). SV

CO

LVEF

LVDD

CI in the treatment group after the treatment were significant statistically compared with the control group before the treatment (P<0.05). Conclusion: Shengui Yixin decoction can be used to treat chronic congestive heart failure (heart function grade Ⅱ-Ⅲ) caused by coronary heart disease and hypertensive heart disease

improve the quality of life

enhance myocardial contractility

reduce myocardial cell damage and delay ventricular reconstruction.