Objective: To observe the therapeutic efficacy of Yinxie capsule combined with Pyrithione Zinc aerosol in the treatment of psoriasis vulgaris and its effect on hemorheology and serum tumor necrosis factor-α(TNF-α)

interleukin-8(IL-8)

matrix metalloproteinases-2(MMP-2)

matrix metalloproteinases-9(MMP-9). Method: Altogether 130 patients with psoriasis vulgaris were divided into the control group and the observation group by random number table

with 65 patients in each group. The control group was treated by spraying Pyrithione Zinc aerosol

three times/d. In addition to the therapy of the control group

the observation group also took Yinxie capsule

4 capsules

tid. The course of treatment were 8 weeks for two groups. psoriasis area and severity index(PASI)

visualanaloguescale(VAS) and dermatology life qualityindex(DLQI) were scored in both groups before and after the treatment. The hemorheology and serum TNF-α

IL-8

MMP-2

MMP-9 were detected before and after the treatment. Result: The markedly effective rate of the observation group was 89.23%

which was superior to the control group (73.85%

P<0.05). After the treatment

the scores of PASI

VAS and DLQI in the observation group were obviously lower than that of the control group (P<0.05). The hemorheological indexes of the observation group were superior to that of the control group after the treatment (P<0.05). The serum TNF-α

IL-8

MMP-2 and MMP-9 in the observation group were lower than that of the control group after the treatment (P<0.05). Conclusion: Yinxie capsule combined with Pyrithione Zinc aerosol in the treatment of psoriasis vulgaris is more effective than the simple use of Pyrithione Zinc aerosol. Its mechanism may be correlated with the reduction in plasma viscosity and serum TNF-α

IL-8

MMP-2 and MMP-9.