Objective: To observe the clinical efficacy of Xuanfei Pingchuan decoction for oral administration combined with asthma I formula for acupoint sticking and iontophoresiss in treating child asthma (intermingled cold and heat symptoms) and their effect on interleukin-4 (IL-4)

γ-interferon (IFN-γ) and immunoglobulin E (IgE). Method: Totally 110 patients with bronchial asthma (intermingled cold and heat symptoms) were divided into the control group (55 cases) and the observation group (55 cases) by random number table. The control group orally took Xuanfei Pingchuan decoction. The observation group received acupoint sticking and iontophoresiss of Xuanfei Pingchuan decoction. The course of treatment was 2 weeks for both groups. The time of cough

wheeze and pulmonary wheezing extinction time were recorded. Before and after the treatment

lung function

peak expiratory flow (PEF)

specific value of the first second forced expiratory volume and forced vital capacity (FEV1/FVC) were detected. The control of asthma was evaluated by asthma control questionnaire (ACQ). Serum IL-4

IFN-γ and IgE were detected before and after the treatment. Result: The obvious effective rate was 92.73% in the observation group

which was superior to 78.18% in the control group (P<0.05). The extinction times of coughing

wheezing and lung wheezing sound in the observation group were obviously shorter than that in the control group (P<0.01). After the treatment

PEF and FEV1/FVC in the observation group were higher than that in the control group (P<0.01). After the treatment

serum IL-4 and IgE in the observation group were lower than that in the control group

but with higher IFN-γ than the control group (P<0.01). According to the chi-square test

the asthma controlling effect in the observation group was better than that in the control group (P<0.05). Conclusion: The curative effect of Xuanfei Pingchuan decoction for oral administration combined with asthma I formula for acupoint sticking and iontophoresiss in treating child asthma (intermingled cold and heat symptoms) is superior to that of the simple administration of traditional Chinese medicine. Its mechanism may be related to the regulation in immune system disorders and the reduction in inflammation reactions.