Objective: To observe the therapeutic efficacy of Huoxue Tongluo decoction combined with Huoluo theray in the treatment of nerve-root type cervical spondylosis (Qi stagnation and blood stasis syndrome) and its effect on serum interleukin-1β(IL-1β)

tumor necrosis factor-α(TNF-α)

interleukin-6(IL-6). Method: Totally 200 patients with nerve-root type cervical spondylosis were divided into the control group (101 cases) and the observation group (99 cases)

respectively by random number table. The control group orally took Gentongping pellet

2 bags/time

2 times/d. The observation group was treated by Huoluo therapy

1 time/d

7 times/course

with an interval of one week between two courses;Meanwhile

it also orally took Huoxue Tongluo decoction

1 dose/d. The course of treatment were 4 weeks for both groups. visual analogue scale(VAS) score and visual analogue scale(CASCS) score were recorded for both groups. Serum IL-1β

TNF-α and IL-6 were detected before and after the treatment. Result: The total effective rate of treatment and control groups was respectively 90.1% and 73.27%

with a significant difference between them (P<0.05). After the treatment

VAS score of the observation group was lower than that of the control group (P<0.01)

while CASCS score in the observation group was obviously higher than that of the control group (P<0.01). After the treatment

high shear

median shear

low shear and plasma viscosity in the observation group was obviously lower than that of the control group (P<0.01)

with significant differences in high shear viscosity of blood and plasma viscosity (P<0.01). Serum IL-1β

TNF-α

IL-6 in the observation group were lower than that of the control group (P<0.01). Conclusion: Huoxue Tongluo decoction combined with Huoluo therapy in the treatment of nerve-root type cervical spondylosis (Qi stagnation and blood stasis syndrome) shows a significant clinical efficacy. Its mechanism may be correlated with the improvement of hemorheology and the reduction in serum IL-1β

TNF-α

IL-6.