Objective: To observe the effect of Xiaoshuan Changrong capsule on hemorheology and coagulation function in patients with Qi-deficiency and blood-stasis type cerebral ischemic stroke. Method: Totally eighty patients with Qi-deficiency and blood-stasis type cerebral ischemic stroke were randomly divided into the observation group and the control group

with 40 cases in each group. The control group was given the conventional therapy;while the observation group was given Xiaoshuan Changrong capsule

0.4 g once

three times daily

in addition to the therapy of the control group. Both groups were treated for 30 days. Before and after the treatment

nerve function defect scale (MESSS)

modified barther index(MBI) were assessed

and hemorheological indexes (whole blood viscosity high shear

low shear

plasma viscosity

hematocrit(HCT)

fibrinogen(Fib)

erythrocyte sedimentation rate(ESR)

coagulation indexes [prothrombin time(PT)

activated partial thromboplastin time(APTT)

platelet oggregation rate(PAR) and D-dimmer] and therapeutic indexes (infarct volume

MESSS score and MBI) were monitored. Result: Before the treatment

hemorheological indexes [whole blood viscosity high shear

low shear

plasma viscosity

HCT

Fib and ESR)

coagulation indexes [PT

APTT

PAR and D-dimmer) and therapeutic indexes (infarct volume

MESSS score and MBI) showed no significant differences between both groups

with the comparability. After the 30-day treatment

total efficiency in the observation group was higher than that in the control group (P<0.05)

and hemorheology indexes

coagulation indexes and therapeutic effect indexes in the observation group were superior to that in the control group (P<0.05

P<0.01)

with no obvious adverse reaction in the observation group. Conclusion: Xiaoshuan Changrong capsule is safe and effective in treating cerebral ischemic stroke. Its action mechanism may be correlated with the improvement in blood rheology and anticoagulant function. [Key words] Xiaoshuan Changrong capsules;cerebral ischemic stroke;Qi-deficiency and blood-stasis;hemorheology;blood coagulation