DANG Yan-qi, DUAN Ju, NI Rong-zhen, et al. Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 213-218.
DANG Yan-qi, DUAN Ju, NI Rong-zhen, et al. Biological Activity and Structure-Activity Relationship of Prenylated Flavonoids[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(17): 213-218. DOI: 10.13422/j.cnki.syfjx.2015170213.
is characterized by the presence of the prenyl side chain on the skeleton of flavonoids. According to the prenyl binding sites
number and type of constructions
prenylated flavonoids are divided into 3 prenylated flavonoids
5 prenylated flavonoids
6 prenylated flavonoids
8 prenylated flavonoids
multiple side-chain prenylated flavonoids
pyran ring prenylated flavonoids and lavender prenylated flavonoids. Prenylated flavonoids show a wide range of biological activities
particularly with significant efficacy in improving the differentiation of stem cells
anti-inflammatory and immunoregulation and cardiovascular protection
mitigating metabolic diseases and osteoporosis
neural protection
anti-tumor
anti-aging and reproductive function. There is a significant correlation between the chemical structure and biological activity of prenylated flavonoids. Therefore
the structure-activity relationship of prenylated flavonoids is particularly important
and provides a theoretical basis for the synthesis of new compounds and function prediction.