Objective: To compare micromeritic properties and dissolution of each ultrafine powder of berberine hydrochloride for improving its dissolution efficiency. Method: Berberine hydrochloride was crushed by vibration mill.Particle size

specific surface area and porosity of samples were detected.The crystal structure of ultrafine powder was analyzed by differential scanning calorimetry (DSC).In vitro dissolution of berberine hydrochloride power was investigated. Result: After crushed

the minium value of d0.9 (90% of particle size cumulative distribution) of berberine hydrochloride could reach 38.78 μm.In a word

specific surface area and porosity varied from grinding time

they significantly increased in 4 minutes;after 4 minute

they decreased with increasing of grinding time.DSC curve indicated that the product of crystallinity decreased in different extent.Dissolution test showed that dissolution effect of berberine hydrochloride powder improved by comparing with the original powder

dissolution effect of the 4 min powder by crushing was the best. Conclusion: After crushed by vibration mill

some powder properties and dissolution of berberine hydrochloride can improve

this study will give a theoretical guidance for clinical medication and formulation development of drugs.