Objective: To establish a determination method for in vitro dissolution of lactones in Xianglian Wan

and reveal its dissloution behavior and key influencing factors. Method: Small cup method and HPLC were used to determine dissolution quantity of costunolide and dehydrocostuslactone from Xianglian Wan under different pH

rotational speed of stirring paddle and tween-80 concentration

cumulative dissolution rate was calculated and dissloution curves were drawn.Origin Pro 8.0 was used to fit dissolution curves with model and calculate dissolution parameters. Result: Under all pH dissolvents and rotational speeds of stirring paddle

cumulative dissolution rate of costunolide and dehydrocostuslactone in 6 hours were less than 50%.When tween-80 concentration exceeding 0.3%

cumulative dissolution rate of these two components in 4 hours both exceeded 90%.With increasing of tween-80 concentration

both T50(the time for dissolution 50%) and Td (the time for dissolution 63.2%) of these two components obviously became shorter

their dissolution speeds became quicker. Conclusion: In vitro dissolution of lactones in Xianglian Wan are not completely

the concentration of surfactant in dissolution medium has significant influence on dissolution of lactones in Xianglian Wan.