Objective: To optimize purification process of Qiangzhi Yishen capsules with macroporous resin. Method: Absorption ratio and elution rate of tenuifolin

paeoniflorin

glycyrrhizic acid and liquiritin were taken as indexes to screen out types of macroporous resins.Effects of the concentration of solution

diameter-height ratio and eluent volume on purification process of Qiangzhi Yishen capsules were investigated by single factor tests. Result: HPD-100 macroporous resin was selected

optimum purification process was as following:the mass concentration of sample loading solution 0.1 g· mL-1

resin-material drug (3:1)

diameter-height ratio of resin 1:7.5

sample loading speed 3 BV· h-1

decontaminated with 4 BV of water

and then eluted with 5 BV of 70% ethanol

elution speed of 3 BV· h-1.Transport rates of tenuifolin

paeoniflorin

glycyrrhizic acid and liquiritin were 78.55%

88.62%

82.47%

83.15%

with rate of extract of 7.52% and drying time of 0.5 h. Conclusion: This process can effectively remove starch

saccharides and other impurities in water extract

these purified substances is easy to use in preparations.