Objective: To establish a method for determination of ten lignans in Schisandrae Chinensis Fructus

and analyze difference of contents of ten lignans in the pulp

seed shell and seed kernel of Schisandrae Chinensis Fructus for researching regularities of their distribution. Method: HPLC was developed for determination of schisandrol A

gomisin D

gomisin J

schisandrol B

angeloylgomisin H

gomisin G

schisantherin A

schisandrin A

schisandrin B and schisandrin C in Schisandrae Chinensis Fructus from different area

mobile phase consisted of acetonitrile-water for gradient elution

detection wavelength was set at 220 nm and injection volume was 4 μL. Result: The content of total lignans in the seed kernel

seed shell and pulp of Schisandrae Chinensis Fructus from different area were 30.08

9.76

2.24 mg· g-1

respectively.Contents of ten lignans in these three parts of Schisandrae Chinensis Fructus showed significant difference

which decreased in the order of the seed kernel> the seed shell> the pulp. Conclusion: The developed method displays distribution information of lignans in three parts of Schisandrae Chinensis Fructus well

which can provide a reference for clinical application of Schisandrae Chinensis Fructus.