Objective: To observe the effect of Sanhuang Huoluo formula on blood glucose

renal function

sterol regulating element binding protein-1c (SREBP-1c) and SREBP-2c of diabetic nephropathy rats. Method: The diabetic model was induced by streptozotocin. The rats in the successfully established diabetic model were randomly divided into the model group

the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups. After other groups took the resection of the right kidney

the positive drug group was given 1.3 mg· kg-1 of benazepril hydrochloride

Sanhuang adjustable low dose group

middle dose group and high dose group were orally given Chinese medicine granules with doses of 5

15

30 g· kg-1

respectively. Both of the normal group and the model group mice were orally given distilled water

and all of the groups orally given drugs for 8 weeks in a row. Blood glucose (GLU)

glycosylated hemoglobin (HbA1c)

blood urea nitrogen (BUN)

creatinine (SCr)

urine protein (Pro)

SREBP-lc

SREBP-2c in rats were observed. Result: Compared with the normal group

GLU and HbA1c of the model group were significantly higher (P<0.01)

GLU and HbA1c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were also significantly higher (P<0.01). Compared with the model group

GLU of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were lower (P<0.01)

HbA1c of the positive drug group and Sanhuang Huoluo formula medium and high doses groups were lower (P<0.01)

HbA1c of the Sanhuang Huoluo formula low dose group was lower (P<0.05). Compared with the normal group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the model group were significantly higher (P<0.01)

and SCr

BUN

Pro

SREBP-lc and SREBP-2c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were also significantly higher (P<0.01). Compared with the model group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the positive drug group and Sanhuang Huoluo formula low

medium and high doses groups were lower (P<0.01). Compared with the positive drug group

SCr

BUN

Pro

SREBP-lc and SREBP-2c of the Sanhuang Huoluo formula low dose group were higher (P<0.01)

and SCr

BUN

Pro

SREBP-lc and SREBP-2c of the Sanhuang Huoluo formula medium dose group were higher (P<0.05). Conclusion: Sanhuang Huoluo formula can improve level of SCr

BUN

Pro

SREBP-lc and SREBP-2c in diabetes nephropathy rats

with a certain protective effect on renal damage in rats of diabetic nephropathy rats.