Objective: To observe the clinical effect of soft capsule of Yindan Xinnaotong combined with DL-thioctic acid in the treatment of diabetic peripheral neuropathy and explore its mechanisms. Method: Ninety-eight patients with diabetic peripheral neuropathy were randomly divided into observation group and control group by the number table method

with 49 patients in each group. The patients in both groups received conventional treatment. The patients in control group were given Lipoic acid injection with 600 mg/time and qd. In addition to the therapy of control group

patients in treatment group were given 4 pieces soft capsules of Yindan Xinnaotong

tid. Both groups received a 4-week treatment. Tactile sensation and temperature sensation were detected by Semmes-weinstein method and Tip Thcrem sensation detector method respectively. Tendon jerk includes knee jerk and ankle jerk. Toronto clinical scoring system (TCSS) was used to evaluate the aforementioned detection. Sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) for median nerve and peroneal nerve in both groups were observed

and blood sugar and blood lipids

the level of serum acetylcholinesterase malondialdehyde (MDA)

nitric oxide (NO)

superoxide dismutase (SOD) and endothelin-1 (ET-1) were compared between two groups. Result: The total effective rate in the treatment group was 89.8%

which was superior to 73.47% in the control group (P<0.05). After treatment

SNCV and MNCV of median nerve for patients in treatment groups were higher than those of control (P<0.05). After treatment

level of blood sugar was decreased in both groups (P<0.05)

but with no significant difference between them. Blood lipids were obviously decreased in treatment group than before the treatment (P<0.01). After treatment

levels of SOD and NO in the treatment group were higher than those of control group (P<0.05)

while levels of MDA and ET-1 in the treatment group were lower than the control group (P<0.05). Conclusion: The curative effect of soft capsule of Yindan Xinnaotong combined with DL-thioctic acid is efficient in treating diabetic peripheral neuropathy

and its mechanism may be related with adjustment of the organism lipid metabolism and levels of MDA

SOD

NO and ET-1.