Objective: To observe the clinical efficacy of oral administration of Bushen Quhan Zhiwang decoction in the treatment of kidney deficiency and blood stasis type knee osteoarthritis(KOA) and its effect on levels ofinterleukin-6(IL-6) and tumor necrosis factor(TNF-α) in serum and synovial fluid. Method: One hundred thirty-seven patients with kidney deficiency and blood stasis type KOA were divided into control group(68 cases)and treatment group (69 cases) by random number table.Three and four cases were dropped during treatment from control group and treatment group respectively.For control group

patients took glucosamine hydrochloride tablets (480 mg/time

3 times/d).In addition to the therapy of control group

patients in treatment group were orally administered with Bushen Quhan Zhiwang decoction(1 dose/d

bid) and lontophoresis(30 min/time

1 time/d). Course of treatment were 6 weeks for both groups.The Western Ontario and McMaster Universities(WOMAC) score was used to evaluated the symptoms and signs of patients in two groups before and after treatment.The hemorheological indexes and levels of IL-6 and TNF-α in the serum and synovial fluid were detected before and after treatment. Result: The effective rate of control group was 87.69%

which was superior to 96.92% of treatment group(P<0.05). The scores for daily activities

joint stiffnessand pain and total score of WOMAC of treatment group were lower than those of control group(P<0.01).The hemorheological indexes in treatment group were superior to those in control group(P<0.01).The levels of IL-6 and TNF-α in the serum and synovial fluid in treatment group were lower than that in control group(P<0.01). Conclusion: Bushen Quhan Zhiwang decoction for oral administration shows significant efficacyin the treatment of kidney deficiency and blood stasis type KOA

and its mechanism may be related with improving blood circulation and reducing inflammatory reaction.