Objective: To discuss the clinical efficacy of Jianpi Yishen Quyu decoction in treating diabetic nephropathy (DN) and its effect on serum levels of inflammatory factors. Method: Eighty patients were randomly divided into control group (40 cases) and research group (40 cases) by random number table. Patients in control group took telmisartan tablets

40 mg/time

1 time/day. In addition to the therapy of control group

patients in research group were given Jianpi Yishen Quyu decoction

1 dose/day. Treatment courses in two groups lasted for 3 months. Before and after treatment

24-hour urine protein quantitation (24 h UPQ)

ratio of microalbuminuria and creatinine (ACR) and cystatin C (CysC) were recorded. And spleen and kidney deficiency and blood stasis blocking collaterals were scored. Levels of high-sensitivity C-reactive protein (hs-CRP)

interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected. Result: Total effective rate in research group was 75%

which was superior to 52.5% of control group (P<0.05). After the treatment

the SCr

BUN

24 h UPQ

UAER

ACR and CysC in the research group were inferior to these in control group (P<0.01). The scores of spleen and kidney deficiency and blood stasis and collateral blocking symptoms in research group reduced to below these in control group at the first

second and third months after the treatment (P<0.01). The scores of spleen and kidney deficiency and blood stasis and collateral blocking in research group decreased faster than that in control group after treatment (P<0.01). Levels of serum hs-CRP

IL-6

TNF-α in research group were lower than these standards in control group (P<0.01). Conclusion: In addition to the conventional western medicine therapy

Jianpi Yishen Quyu decotion can be administered to improve DN renal function at early stage

reduce albuminuria and glomerular filtration rate

relieve the clinical symptoms and inflammation reaction. Its clinical curative effect is superior to that of simple western medicine treatment measures.