Islet beta cell dysfunction and decrease play an important role in the occurrence and development of type 2 diabetes mellitus(T2DM). The effect of traditional Chinese medicine (TCM) on the protection of islet beta cells was recognized and plays a crucial role in the prevention and control of type 2 diabetes. The protective mechanism of TCMs' extracts

monomer and compounds to islet beta cells were summarized to define their effect in protecting islet beta cells and treating T2DM. Some TCMs can promote islet beta cell proliferation

reduce islet beta cells apoptosis

and protect islet beta cells indirectly by promoting islet beta cell proliferation

reducing islet beta cell apoptosis

improving serum and pancreatic tissue oxidative stress

improving islet cell insulin resistance

improving the level of glucagon like peptide-1(GLP-1)

improving pancreas microcirculation

regulating autophagy level. Because of the complexity of the traditional Chinese medicine ingredients and compound formula

their protective effect on islet beta cells involves a variety of targets and mechanisms. Besides

under the guidance of general concept of TCMs

TCMs have a higher safety in treating T2DM. Therefore

TCMs have a broad prospect to protect islet beta cells. With the development of biotechnology

it is possible to screen out new diabetes drugs from TCMs.