Objective: To study the relationship between the inflammation and expression of hepatic purinergic receptors P2X7 and A2A in hyperlipidemia rats

and the intervention effect of Yirui capsule. Method: Fifty male rats were randomly divided into two groups. Ten rats were fed with normal diets as normal group

and forty rats were fed with high-fat diets as the observation group. After 14 d

the forty rats were further randomly divided into model group and Yirui capsule low

middle

high dose groups

10 rats for each group. Yirui capsules were administered ig to the treatment group for 30 days at 140

280

560 mg·kg-1 respectively. And then

the levels of lipids in serum were detected

tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in serum were detected by enzyme-linked immunosorbant assay(ELISA)

and the expression of purinergic receptors P2X7 and A2A in livers were analyzed by RT-PCR. Result: The content of inflammatory cytokines TNF-α

IL-1β and the expression of purinergic receptors P2X7 and A2A in livers were increased in model group

compared with normal group (P<0.01). The content of inflammatory cytokines TNF-α

IL-1β and the expression of purinergic receptors P2X7 and A2A in livers were decreased in Yirui treatment group

compared with model group (P<0.01). Conclusion: Yirui capsule can regulate the expression of purinergic receptors in rat's liver

which is possibly relevant to the anti-inflammatory properties and amendment of lipid metabolism.