Objective: To observe the therapeutic efficacy of Naogengtong decoction combined with Shuxuening injection on hemiplegia in recovery stage of cerebral infarction and its impact on interieukin-6(IL-6)

interieukin-10 (IL-10)

tumor necrosis factor (TNF-α)

matrix-metalloproteinase-9 (MMP-9). Method: Eighty-eight patients of cerebral infarction were randomly divided into control group and observation group of 44 patients each by random number table. Both groups received conventional treatment. In control group

patients received Shuxuening injection (iv gtt and qd). The patients in observation group were also treated with Naogengtong decoction (1 dose/d and bid) by oral administration based on the treatment of control group. Course of treatment were 4 weeks for both groups. Barthel Index (BI)

Fugl-Meyer score (FMMS)

disability rate

CSS score

and improved Ashworth score were compared between two groups. IL-6

IL-10

TNF-α

and MMP-9 in serum were detected and compared between two groups. Result: The clinical efficacy in observation group was superior to that of control group by ridit analysis (P<0.05). The BI and FMMS score of upper and lower limbs in the observation group were higher than those of control group (P<0.01). After treatment

the disability rate in control group and observation group was 25.12% and 15.39% respectively

which showed no statistical significance.After treatment

CSS scores and improvement Ashworth scores in observation group were lower than those in control group (P<0.01). IL-6

IL-10

TNF-α and MMP-9 levels in observation group were lower than those in control group (P<0.01). Conclusion: Naogengtong decoction combined with Shuxuening injection can improve activity of daily living

FMMS score

muscular tension

and neurologic impairment in patients with hemiplegia in recovery stage of cerebral infarction

and its mechanism may be related with inhibiting the inflammatory response and down-regulating the level of MMP-9.