Objective: To explore the clinical efficacy of Jiannaoling tablets combined with compound Yinxing Tongmai oral liquid in treatment of vascular cognitive impairment(VCI) and its impact on inflammation response and oxidative damage. Method: Ninety patients with VCI were randomly divided into control group (45 cases) and observation group (45 cases) by number table method. Patients in control group orally took Nimodipine tablets

20 mg/time

1 time/day;donepezil hydrochloride tablets

5 mg/time

1 time/day. The patients in observation group also took Jiannaoling tablets

4 pieces/time

3 times/day and Yinxing Tongmai oral liquid

10 mL/time

3 times/day based on the treatment of control group. Treatment course was 12 weeks in both groups. Minimum mental state examination(MMSE) and Montreal cognitive assessment scale (MoCA) were taken to evaluate cognitive function.The activity of daily living (ADL) scale was used to test the quality of life

and dialectical scale of vascular dementia (DSVD) was taken once both before and after treatment to evaluate the traditional Chinese medicine syndrome. Superoxide dismutase (SOD)

malondialdehyde (MDA)

C-reactive protein (CRP)

tumor necrosis facor α (TNF-α) and homocysteine (Hcy) were detected both before and after therapy. Result: By Ridit analysis

the cognitive effect in observation group was superior to that in control group after treatment (P<0.05). MoCA

MMS and ADL scores in observation group were higher than these in control group after treatment

while the DSVD score was lower than that in control group (P<0.01). The scores in directional force

attention and calculation force and language ability in MMSE scale in observation group were higher than the data in control group (P<0.01). CRP

Hcy

TNF-α and MDA levels in observation group were lower than those in control group

wile SOD was higher than that in control group (P<0.01). Conclusion: Based on the conventional western medicine treatment

Jiannaoling tablets combined with compound Yinxing Tongmai oral liquid can improve the cognitive function in patients with vascular cognitive impairment

reduce clinical symptoms and enhance the activities of daily living. Its mechanism may be related to reducing inflammation and oxygen free radical damages.