参麦注射液对急性心肌梗死病死率影响的系统评价及试验序贯分析

王震; 鞠建庆; 李运伦

doi:10.13422/j.cnki.syfjx.2015190189

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参麦注射液对急性心肌梗死病死率影响的系统评价及试验序贯分析

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- 参麦注射液对急性心肌梗死病死率影响的系统评价及试验序贯分析
- Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction
- 中国实验方剂学杂志 2015年21卷第19期页码：189-193
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81273700)
- DOI：10.13422/j.cnki.syfjx.2015190189
  中图分类号： R285.6
- 纸质出版日期：2015
- 稿件说明：
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王震, 鞠建庆, 李运伦. 参麦注射液对急性心肌梗死病死率影响的系统评价及试验序贯分析[J]. 中国实验方剂学杂志, 2015,21(19):189-193.

WANG Zhen, JU Jian-qing, LI Yun-lun. Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 189-193.
王震, 鞠建庆, 李运伦. 参麦注射液对急性心肌梗死病死率影响的系统评价及试验序贯分析[J]. 中国实验方剂学杂志, 2015,21(19):189-193. DOI： 10.13422/j.cnki.syfjx.2015190189.

WANG Zhen, JU Jian-qing, LI Yun-lun. Systematic Evaluation and Trial Sequential Analysis of Shenmai Injection on Mortality Rate of Patients with Acute Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(19): 189-193. DOI： 10.13422/j.cnki.syfjx.2015190189.

摘要

目的:系统评价参麦注射液对急性心肌梗死病死率的影响。方法:检索电子数据库

搜集以病死率为结局评价参麦注射液治疗急性心肌梗死(AMI)的随机对照试验

进行系统评价和Meta分析

并按照发表年份进行累积Meta分析

然后采用序贯试验分析(TSA)的方法对结果进行检验。结果:共纳入16项合格研究

Meta分析和累积Meta分析结果显示参麦注射液可降低AMI的病死率

[RR=0.61

99%CI(0.43

0.85)]

[RD=-0.06

99%CI(-0.09

-0.03)

NNT≈15.3]

TSA分析进一步确证了该结果。结论:参麦注射液可降低AMI患者的病死率

但由于研究的局限性

仍建议今后开展设计合理、执行严格的临床试验以提供更加真实可靠的证据。

Abstract

Objective: To systematically assess the efficacy of Shenmai injection on the mortality rate of patients with acute myocardial infarction (AMI). Method: Randomized controlled trials for evaluating Shenmai injection for AMI patients with the mortality rate as an outcome were collected from electronic databases for a systematic evaluation and meta-analysis. Besides

a cumulative meta-analysis according to the year of publication was conducted

and trial sequential analysis (TSA) was also adopted to test their results. Result: Sixteen qualified trials were included. Meta-analysis and cumulative meta-analysis indicated that Shenmai injection can decrease the mortality rate of AMI patients

with RR=0.61

99%CI (0.43

0.85)

RD=-0.06

99%CI (-0.09

-0.03)

NNT≈15.3.TSA further verified the results. Conclusion: Shenmai injection can decrease the mortality rate of patients with AMI. Due to the limitations of the study

clinical trials with rational design and strict execution shall be carried out in the future to provide more reliable evidence.

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