Objective: To systematically evaluate the effectiveness and safety of Zhengtian pill for migraine. Method: The randomized controlled trails(RCTs) of Zhengtian pill and conventional western medicine or placebo in treating migraine were searched in domestic and overseas databases through computer. Literature screening

information extracting and literature quality assessment were completed by 2 reviewers independently. And Revman 5.3.0 software was adopted for the meta analysis. Result: Totally 15 RCTs involving 956 patients were included. The results showed that when compared with the control group

Zhengtian pill combined with Nimodipine group was superior in the total effective rate[RR=1.44

95%CI(1.2

1.74)

P=0.000 1]

Zhengtian pill combined with Flunarizine group had a better effective rate[RR=1.21

95%CI(1.08

1.35)

P=0.000 9] and a shorter headache duration[MD=-0.84

95%CI(-12.03

-4.88)

P<0.000 01];when compared with the aspirin group

Zhentian pill group had no statistical difference in the total effective rate[RR=1.21

95%CI(0.99

1.49)

P=0.06];when compared with the placebo group

Zhentian pill had a better effective rate[RR=2.5

95%CI(1.83

3.41)

P=0.000 01]

shorter headache duration[MD=-1.31

95%CI(-1.60

-1.02)

P<0.000 01]

lower frequency of headache[MD=-1.42

95%CI(-1.81

-1.03)

P=0.000 01]

less episode days[MD=-1.25

95%CI(-1.91

-0.60)

P<0.000 01]

decreased headache degree[MD=-1.11

95%CI(-1.43

-0.79)

P<0.000 01] and better conditions for the accompanied symptoms such as nausea[MD=-1.11

95%CI(-1.27

-0.95)

P<0.000 01]

photophobia[MD=-0.43

95%CI(-0.81

-0.28)

P<0.000 01] and less tears[MD=-0.54

95%CI(-0.7

-0.38)

P<0.000 01]. But the existing evidences cannot verify the relations between Zhengtian pill and reported adverse events. Conclusion: The current evidences showed that Zhengtian pill is effective in treating migraine

with better effects than placebo in reducing headache degree and headache duration and relieving accompanied symptoms

and equal overall response rate with Aspirin in treating migraine. The combination of Zhengtian pill and Nimodipine or Flunarizine had a better efficacy than simple administration of western medicine. But more RCTs with higher qualities are required to confirm the reliability and extrapolation of our conclusion.