Objective: To observe the protect effects of Baogan granules on acute chemical liver injury of mice induced by carbon tetrachloride (CCl4). Method: Ninety Kunming mice were randomly divided into normal group

model group

hugan tablet group(0.7 g·kg-1)

baogan granules high

middle

low dose group(12.9

6.45

3.225 g·kg-1). Mices were given medicine once a day continuing 30 days. 1h after the last administration

in addition to the normal l group

each group respectively ip 0.1%CCl4 10 mL·kg-1

acute chemical liver injury in mice model was established. 24 h after death mice

collect liver tissue and serum specimens

detection of serum glutamic acid transaminase (ALT)

aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activity;determination of liver tissue total superoxide dismutase (T-SOD) activity

reduced glutathione (GSH) and malondialdehyde (MDA) content and hepatic histopathological examination. Result: Baogan granules can significantly reduce liver damage ALT

AST and LDH level in mice (P<0.05)

Increase the T-SOD activity and GSH content (P<0.05)

Reduce the MDA content in liver homogenate (P<0.05)

and show concentration-response relationship;Greatly improve the pathology of liver tissue injury. Conclusion: Baogan granules on CCl4 induced acute chemical liver injury in mice has antioxidant and protect liver function function.