Objective: To observe the effects of Shugan Xiaozhi decoction on blood lipid indicators of non-alcoholic steatohepatitis rats. Method: Sixty Wistar male rats were randomly divided into control group

hyper-lipidemia model group

fenofibrate group (0.1 g·kg-1·d-1)

Shugan Xiaozhi decoction high dose group

medium dose group and low dose group (high

medium and low doses refer to four times

two times and one time equivalent to the adult dose). All other groups except the control group were given with high fat diet to copy non-alcoholic steatohepatitis rats model

and received corresponding medicine at the same time

but the control group and hyper-lipidemia model group received distilled water. After 8 weeks

blood lipid cholesterol (TC)

triglyceride (TG)

free fatty acid (FFA)

liver function alanine transaminase (ALT)

aspertate aminotransferase (AST) and blood rheology were detected. Result: Compared with the model group

the levels of following indicators were obviously decreased in Shugan Xiaozhi decoction high dose group

medium dose group and low dose group:TG

TC

FFA

whole blood viscosity (low shear)

plasma viscosity

red blood cell aggregation index

ALT

and AST (P<0.01). Conclusion: Shugan Xiaozhi decoction has the effect of lowering blood lipid levels

protecting liver and diminishing enzymes in non-alcoholic steatohepatitis rats.