Objective: To investigate the clinical effect of Danhong injection in combination with clopidogrel in the treatment of patients with unstable angina pectoris (UAP) and its effects on level of blood lipids and inflammatory factors. Method: The 142 cases of eligible UAP patients treated in our hospital were randomly divided into the control group (n=72) and the observation group (n=70). Besides conventional treatments

the control group was also treated with clopidogrel

while the observation group was also treated with Danhong injection combined with clopidogrel. Then

the curative efficacy

total cholesterol (TC)

triglyceride (TG)

low density lipoprotein cholesterol (LDL-C)

high density lipoprotein cholesterol (HDL-C)

tumor necrosis factor-α (TNF-α)

interleukin-1 (IL-1)

interleukin-6 (IL-6) and adverse reactions of the two groups were compared. Result: The observation group had a therapeutic efficiency ratio of 95.7%

which was significantly higher than that of 84.7% in the control group (P<0.05). The observation group had a therapeutic efficiency ratio of 92.9% on blood stagnaton type

which was significantly higher than that of 73.6% in the control group (P<0.05). Compared with the control group

after the treatment

levels of total cholesterol [TC

(4.60±0.24) VS (5.12±0.32) mmol·L-1]

triglyceride [TG

(1.82±0.32) VS (2.41±0.27) mmol·L-1]

low density lipoprotein cholesterol

[LDL-C

(2.61±0.34) VS (3.36±0.33) mmol·L-1] were respectively statistically lower and levels of density lipoprotein cholestero[HDL-C

(1.71±0.22) VS (1.35±0.23) mmol·L-1] was statistically higher in the observation group (P<0.05). As for inflammatory factors

levels of tumor necrosis factor-α [TNF-α

(54.21±9.57) VS (65.34±9.27) ng·L-1]

interleukin-1 [IL-1

(0.28±0.09) VS (0.45±0.11) ng·L-1] and IL-6 [(6.28±3.24) VS (9.55±3.64) ng·L-1] were statistically lower in the observation group than those in the control group after the treatment (P<0.05). During the treatment

there was no case of severe adverse reaction. The incidence of adverse reaction in the observation group was 8.6%

which was statistically the same with that of 11.1% in the control group. Conclusion: The combined administration of Danhong injection with clopidogrel for treating UAP is effective

which can significantly increase the curative efficiency

improve level of blood lipids and alleviate inflammatory reaction with minor adverse reaction

and is worth further studing in clinic.