Objective: To observe the clinical efficacy of Jiawei Qianghuo decoction combined with lonphoresis in the treatment of cervical spondylotic radiculopathy(CSA) with anemofrigid-damp arthralgia syndrome and its influence on hemorheology and interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) in serum. Method: One hundred and thirty four patients with CSA were randomly divided into control group and treatment group according to number table

with 67 patients in each group. The control group was treated with Gentongping granule (8 g/1 time and 2 times/d) and massage manipulation with relax and traction on cervical vertebra (20 min/1 time and 1 time/d). Treatment group was given with additional Jiawei Qianghuo decoction (1 dose/d and oral

bid) and another Jiawei Qianghuo decoction was grinded into coarse powder

soaked in 75% wine for 1 month and heated for 10 min when it is used by iontophoresis (25 min/time

qd). The treatment course was 4 weeks for both groups. Clinical effect of both groups was compared. Subjective symptoms

adaptability

and clinical physical signs were assessed by the clinical assessment scale for cervical spondylosis (CASCS). Pain rating index (PRI) was adopted to evaluate the pain in both groups. IL-1β and TNF-α changes before and after treatment were analyzed in both groups. Result: The total effective rate of the treatment group and control group was 91.04% and 77.61% respectively

with significant difference between two groups (P<0.05). Each and total scores for CASCS in treatment group after treatment were higher than those in control group (P<0.05). Clinical symptoms and PRI scores in treatment group after treatment were significantly lower than those in control group(P<0.05). After treatment IL-1β and TNF-α in serum in treatment group were lower than those in control group (P<0.05). Conclusion: Oral Jiawei Qianghuo decoction combined with iontophoresis can improve clinical symptoms

physical signs and adaptability

relieve pain and reduce IL-1β and TNF-α in serum

with a good therapeutic effect.