Objective: To explore the effect of different extracts from Amygdalus mongolica on blood lipid

lipid peroxidation and liver function of hyperlipidemia rats. Method: A. mongolica kernel was extracted by ethyl acetate

n-butanol and water in sequence. A total of 60 male Wistar rats were selected and randomly divided into 6 groups: normal control group (10) and model control groups (50)

including positive drug group (Xuezhikang

0.061 7 g·kg-1)

ethyl acetate extract group (2.0 g·kg-1)

n-butanol extract group (2.0 g·kg-1) and water extract group (2.0 g·kg-1). The hyperlipidemia model was induced by method of high lipid feed. After seven weeks of intervention of with drugs

total cholesterol(TC)

triglyceride(TG)

high-density lipoprotein cholesterol(HDL-C)

low-density lipoprotein cholesterol (LDL-C)

aspartate transaminase(AST)

alanine aminotransferase(ALT)

malondialdehyde(MDA)

superoxide dismutase(SOD)

peroxidase(POD)

catalase(CAT)

glutathione (GSH) and glutathione peroxidase(GSH-Px) in serum were tested

and the atherosclerosis index(AI) and the ratio of LDL-C/HDL-C were analysedcalculated. Result: As compared with the normal group

the model group showed significantly higher TC

LDL-C

AST

ALT

AI

LDL-C/HDL-C and MDA (P<0.01). Compared with the high-lipid model group

the n-butanol extract group revealed significantly lower TC

LDL-C

AST

AI

LDL-C/HDL-C

MDA(P<0.05) but remarkably higher SOD

POD

GSH-Px(P<0.05). POD was significantly higher (P<0.05) in water extracts group. Conclusion: n-butanol extracts of A. mongolica could significantly decrease the blood lipid level

resist lipid peroxidation level in rats

reduce the risk of cardiovascular disease

protect liver function of rats. n-butanol extracts of A. mongolica could also decrease oxidative stress and lipid peroxidase accumulation in liver

which may be one of effective mechanisms to reduce blood lipid.