Objective: To investigate the effect of compound aloe vera gel on radioactive dermatitis in rats by establishing the animal model of Ⅱ degree radioactive dermatitis rats. Method: SD rat models of Ⅱ degree radioactive dermatitis were established by changing radiation modes

with rats as the experimental animals and on the basis of collecting and concluding all relevant literatures. These rats were divided into model group

normal group (matrix)

positive drug group (triethanolamine cream

400 g·kg-1)

compound aloe vera gel high dose group

middle dose group and low dose group (600

400

200 g·kg-1). After 2 weeks

the pharmacodynamics study of compound aloe vera gel was done with wound healing rate

wound morphological observation and wound histological observation as the outcome measures. Result: Compared with the normal group

the model group had larger wound redness and swelling area

more wound discharges

no scars and lower healing rate (P<0.01). Compared with the model group

the wound healing rate in triethanolamine cream group

compound aloe vera gel high and middle dose groups was significantly increased (P<0.01)

and these groups could accelerate wound healing and reduce wound discharges. Histopathology examination showed that the wound injury was obvious in model group

but triethanolamine cream group

compound aloe gel high

middle dose groups can reduce the damage of wound. Conclusion: High and middle dose compound aloe vera gel and triethanolamine cream have equivalent therapeutic effect in rats with radiation dermatitis.