Objective: To investigate the clinical effect of Danggui Zhantong Tang combined with Sanmiao Wan to treat damp-heat accumulation type gouty arthritis and its influence on Dickkopf-1 (DKK-1) and tartrate-resistant acid phosphatase 5 b (TRAP5 b) contents. Method: One hundred and twenty-two cases with damp-heat accumulation type gouty arthritis were randomly divided into the treatment group and control group according to method of random digits table 61 patients. Conventional treatment was given to all patients in both groups. Control group was orally given with colchicines tablets (with 1 mg dose at the initial and 0.5 mg·h-1 until symptoms relieved

and then 0.5 mg/time

tid) and meloxicam dispersible tablets (7.5 mg/time

bid). Treatment group was added with Danggui Zhantong decoction (1 dose/d

bid) combined with Sanmiao pills (9 g/time

tid) based on the treatment in control group. Course of treatment lasted for 1 week for both groups. Clinical symptoms and signs

blood uric acid (BUA) levels

visual analogue scale (VAS) scores

and syndrome of traditional Chinese medicine (STCM) scores were compared between two groups before and after treatment. Serum DKK-1 and TRAP5 b levels were detected in two groups before and after treatment. Result: The total effective rate was 95.08% in treatment group

higher than 80.33% in control group (P<0.05). Symptoms and signs scores in treatment group after treatment were significantly lower than those in control group (P<0.01). After treatment

BUA leves

VAS score

and STCM score in treatment group were significantly lower than those in control group

with statistically significant difference (P<0.01). After treatment

DKK-1 and TRAP5 b levels in the treatment group were significantly lower than those in control group

with statistically significant difference (P<0.05). Conclusion: Based on conventional processing and treatment with western medicine

Danggui Zhantong decoction combined with Sanmiao pills can effectively control the clinical symptoms and signs of acute gouty arthritis (damp-heat accumulation type)

relieve pain

reduce BUA level

improve STCM

and its mechanisms may be associated with reducing DKK-1 and TRAP5 b levels in serum.