Objective: To investigate clinical effects of Sijunzi Tang

Astragalus Radix assisted with diet exercise therapy in treatment of gestational diabetes mellitus with deficiency of Qi and Yin type. Method: Two hundred and forty patients with gestational diabetes mellitus with deficiency of Qi and Yin type were chosen in recent years in our hospital and randomly divided into both group including control group (120 patients) with routine diet exercise therapy and traditional Chinese medicine(TCM) group (120 patients) with Sijunzi Tang combined with astragalus on the basis of control group; and the clinical efficacy

levels of blood glucose

blood lipids and renal function index before and after treatment and pregnancy outcome of both groups were compared. Result: The clinical efficacy of control group and TCM group were separately 78.33%

91.67%; the clinical efficacy of TCM group was significantly better than control group (P<0.05). The value of fasting plasma glucose(FPG)

2 h plasma glucose(2 hPG) and glycated hemoglobin A1c(HbA1c) of control group after treatment were separately (9.77±1.03)mmol·L-1

(11.30±1.64)mmol·L-1

(9.84±1.10)%. The value of FPG

2 hPG and HbA1c of TCM group after treatment were separately (5.48±0.62)mmol·L-1

(8.62±1.27)mmol·L-1

(7.03±0.64)%; the levels of blood glucose

blood lipids and renal function index after treatment of TCM group was significantly better than control group and before treatment(P<0.05). The incidence of preterm birth

preeclampsia

polyhydramnios

neonatal respiratory distress syndrome and neonatal hyperbilirubinemia of TCM group was significantly lower than control group(P<0.05). There was no significant difference in incidence of cesarean section and pregnancy induced hypertension between 2 groups. Conclusion: Sijunzi Tang

astragalus assisted with diet exercise therapy in treatment of gestational diabetes mellitus with deficiency of Qi and Yin type can efficiently relieve the diabetes symptoms

control the levels of blood glucose and blood lipid

improve the renal function and have the positive effect on the pregnancy outcome.