Objective: To observe the effect of tonifying kidney anti-hypertension decoction on SHR with abnormal blood lipid and blood glucose and adiponectin pathway. Method: Totally 40 5-week-old clean grade SHRs were randomly divided into the normal diet group and high-fat group. After the modeling at the 8th week

the high-fat group rats were divided into three groups:model group (blank SHR with abnormal glucose and lipid metabolism)

captopril group and tonifying kidney group (tonifying kidney anti-hypertension decoction). After the treatment of 8 weeks

the rats were killed to test their blood pressure

glucose

blood lipid and insulin. Myocardial tissue sections were stained with HE to observe the pathological changes in heart. The content of ADP in serum was detected by Elisa assay. Result: Before the treatment with drugs

blood pressure of SHRs with a high sugar and fat diet had no statistical difference. Blood pressure of groups with a high sugar and fat diet was higher than those with normal diet (P<0.05). After the modeling at the 4th week

compared with the model group

captopril group showed a lower blood pressure significantly (P<0.05). After 8 weeks

compared with the model group

captopril group and tonifying kidney group showed statistically significant difference in the blood pressure (P<0.01). Compared with SHR group

model group

captopril group

tonifying kidney group showed decreased adiponectin

and model group had significant difference (P<0.05). In PPAR-mRNA of heart

the model group

captopril group and tonifying kidney group were higher than SHR group. Compared with the model group

captopril group and tonifying kidney group were lower. The expressions of AdipoR1 protein in model group

captopril group and tonifying kidney group were higher than that in SHR group. Compared with the model group

captopril group and tonifying kidney group were lower. AdipoR2 protein expression in model group

captopril group and tonifying kidney group were higher than that in SHR group. Compared with the model group and the captopril group

tonifying kidney group had a decreasing tendency. Conclusion: Tonifying kidney anti-hypertension decoction can regulate the abnormal blood lipid and blood glucose of SHRs and protect their hearts. Its mechanism may be correlated with the regulation of adiponectin pathway.