In conjunction with the title search and MeSH retrieval from CNKI

Pubmed

Web of science and other databases

we screened literature mentioned mechanisms of neuropathic pain(NP) for Chinese medicine intervention in the past 20 years. By Summarizing and analysising the literature

70 articles were selected

and the main aspects that mentioned for NP treatment with Chinese medicine are as following:descending inhibition/facilitation systems

ion channels

membrane receptors

neuroinflammation

glial cell activation

signaling pathways

antiapoptotic

antioxidative stress

enzyme activity inhibition

et al. Collectively

Chinese medicine treatment for NP hyperalgesia are effective

with characteristics of multitargets intervention

not only by inhibiting nerve impulses

Chinese medicine can also improve NP neurogenic inflammation

Chinese medicine intervention for NP neuroinflammation gradually attracted scholars' attention

yet

in-deep studies are further needed.