Objective: To develop rapid determination models of water and schisandrin in Schisandra Chinensis Fruit using near infrared (NIR) spectroscopy. Method: 93 batches of Schisandra Chinensis Fruit samples were collected from different regions of China. Near infrared spectrum correction models for determinations of schisandrin and water contents in samples were developed with the application of partial least squares regression. The reference analyses were performed with oven-drying method and ultra performance liquid chromatography method respectively for water and schisandrin. Correlation coefficient and predicted root mean square error were also used for evaluating the estimated performance of models. Result: The correlation coefficients for calibration models were 0.8767 and 0.8890 respectively for water and schisandrin;and root mean square error of prediction set was 0.121and 0.0219 respectively. Conclusion: This established near infrared spectrum method is rapid

reliable and has no pollution

which can be used for the quality evaluation of Schisandra Chinensis Fruit on site.