Objective: To study the effect of Xiaoer Qingwen Jiere Granule in regulating immune function in mice

and its antibacterial efficacy in vitro or in vivo. Method: Totally 70 Balb/C mice were divided into following groups:normal

model

Yupingfeng granule

thymosin

and low

medium

high doses of Xiaoer Qingwen Jiere granules (10.92

21.84

43.68 g crude drug/kg) according to body weight

with 10 in each group. Immune deficiency model was constructed through intraperitoneal injection with cyclophosphamide in all groups except for the normal group

in order to observe the influence of Xiaoer Qingwen Jiere granule on the T or B lymphocyte proliferation

carbon clearance ability and serum and hemolysin content. ICR mice were randomly divided into seven groups by weight:model group

amoxicillin group (370 mg·kg-1)

Xiaoer Ganmaoning mixture group (8.25 mL·kg-1) and low

medium

high-dose Xiaoer Qingwen Jiere granules groups

with 20 to 22 mice in each group. Bacterial infection model was constructed through intraperitoneal injection with Staphylococcus aureus to observe the animal mortality rate

drug protection and the average survival days of animals. The minimal inhibitory concentrations (MIC) of S. aureus

S. epidermidis

Escherichia coli

Candida albicans were observed by using the tube method Qingwen Jiere. Result: Low and medium doses of Xiaoer Qingwen Jiere granules can increase the lymphocyte proliferation induced by lipopolysaccharide(LPS) and Concanavalin(ConA) significantly. In the model induced by staphylococcus aureus

Xiaoer Qingwen Jiere granules can reduce the mortality significantly and prolong the survival time and inhibite S. aureus(P<0.05

P<0.01)

S. epidermidis

E. coli

C. albicans to varying degrees. Conclusion: Xiaoer Qingwen Jiere granule can improve the immune function of immune compromised mice

protect the mice infected by staphylococcus aureus from death in vivo

and inhibit the growth of a variety of bacteria inordinately.