We searched CNKI

Wanfang data

PubMed and reference lists of identified articles(As of September 1

2014)

and reviewed literature

summarized extraction and separation technology of effective components in the most common Chinese medicines for cardiovascular disease.The most common extraction methods were refluxing extraction

ultrasonic extraction

microwave extraction

supercritical extraction

enzyme method

flash extraction and so on

but these researches were usually for laboratory scale.Single factor design

orthogonal design

uniform design and etc were widely used for optimization of extraction method.Water and different concentration of ethanol were always used as extraction solutions.The most common separation methods were macroporous resin

solvent extraction and precipitation method

and the later two methods usually used with macroporous adsorption resin.Some new separation techniques

such as ultrafiltration method

biological transformation technology and molecular imprinting technique

were also used.This article can provide a literature basis for extraction and separation method of Chinese medicines in cardiovascular disease.