Objective: Preparation and evalution of baicalin molecularly imprinted polymer prepared by precipitation polymerization. Method: The molecularly imprinted polymers (MIPs) microsphere which using baicalin as template molecule

acrylamide (AM) as function monomer

ethyleneglycol dimethacrylate (EGDMA) as cross-linker were synthesized by precipitation polymerization. The surface morphologies and characteristics of the MIPs were characterized by transmission electron microscope (TEM) and infrared spectroscopy (IR). The adsorption properties of the polymers for the template molecule

baicalin

were determined respectively by the static adsorption equilibrium experiments

dynamic adsorption equilibrium experiments and selective experiments. Result: The results of above experiments show that dispersivity which using the precipitation polymerization of polymer molecules is excellent

the morphology have a high quality

and the particle size distribution is uniform. On the other hand

the experiment shows that molecular imprinted polymers have higher selective ability and stronger binding capacity for baicalin by precipitation polymerization. Conclusion: The molecular imprinting technology (MIT) provide a new way for the efficient separation and enrichment from the natural product of baicalin.