Objective: To analyze factors affecting formulation of quercetin liquid proliposomes and evaluate its quality. Method: Quercetin liquid proliposomes was prepared.Taking particle size and encapsulation efficiency as indexes

formulation of quercetin liquid proliposomes was optimized by single factor experiment and orthogonal test.Free quercetin and quercetin proliposomes was separated by dialysis method

the content of quercetin was determined by HPLC

stability of quercetin proliposomes in artificial gastric juice and artificial intestinal juice was investigated. Result: Optimum formulation of quercetin liquid proliposomes was as follows:lecithin as lipid membrane material

cremorphor RH40 as surfactant

drug phospholipids ratio of 1:20

cremorphor RH40 amount of 20% to total content of phospholipid and main drug

the concentration of quercetin of 10 g·L-1.The particle size

Zeta potential and encapsulation efficiency of the proliposomes after hydration were (228.7±2.61) nm

(-21.2±1.47) mV and (93.12±1.18)% with good stability within 12 h and good repeatability.It was suitable for oral administration. Conclusion: Quercetin liquid proliposomes has good in vitro properties.Within 12 h

its particle size do not change significantly in each aqueous medium.