Objective: To explore the effects of the leaves of Nauclea officinalis tableton on acute pharyngitis of rat models. Method: Rats were randomly divided into 6 groups

normal group

model group

aspirin group(0.20 g·kg-1)

the leaves of N. officinalis tablets groups(25.8

12.9

6.5 g·kg-1).Each drug was administrated to mice orally twice a day for 3 days.Their commonly living conditions and bacterial colony were observed

the pharyngeal tissues were pathologically examined

the nitric oxide(NO) and myeloperoxidase(MPO)of the pharyngeal tissues and serum were determined

and the temperature were tested by directly spraying ammonia water and applying Staphylococcus aureus into pharyngeal mucosa. Result: The leaves of N. officinalis tablet could be decrease the content of NO and MPO in the pharyngeal tissues and serum

and also decrease the temperature;pathologic changes of rats with actue pharyngitis were improved in different degree;the leaves of N. officinalis tablets restrain the growth of the bacteria. Conclusion: The leaves of N. officinalis tablet has a good curative effect on acute pharyngitis.