Objective: To observe the clinical efficacy of Jiannao Bushen pills combined with Ginkgo Leaves tablet (GLT) in treating mild cognitive impairment (MCI) and its influence on oxidative stress and acetylcholinesterase (AChE). Method: Sixty cases MCI patients were randomly divided into the control group and treatment group according to the method of random digits table

30 patients for each group. Besides

another 30 healthy volunteers were selected as the normal group. The control group received Donepezil hydrochloride tablets

2.5 mg·d-1after meals. The treatment group received Jiannao Bushen pills(15 pieces/time

2 times/d) combined with GLT (2 tablets/time

3 times/d)

with the treatment course of 3 months for both groups. Changes of scores of all indexes of clinical memory scale and memory quotient (MQ) before and after treatment were observed for both groups

and clinical therapeutic effect was evaluated by using MQ increasing values. Change of malondialdehyde (MDA)

superoxide dismutase (SOD)

and AChE levels before and after treatment were observed. Result: All indexes of clinical memory scale and MQ in MIC patients were significantly lower than those in normal group (volunteers) (P<0.01). After treatment

the satisfaction rate was 46.67% in the control group and 76.67% in the treatment group

with significant difference between the two groups (P<0.05). After treatment

the scores of all indexes of clinical memory scale of two groups except associated memory were significantly increased (P<0.05

P<0.01) in both groups

while the scores in direction memory

picture free memory

associated memory of human picture characteristics

and MQ in the treatment group were higher than those in the control group (P<0.05). Serum MDA and AChE levels were decreased and SOD was increased in both groups after treatment (P<0.05

P<0.01). Serum MDA and AChE levels in the treatment group were lower than those in control group after treatment

while SOD level in the treatment group was higher than that in the control group after treatment (P<0.05). After treatment

there was no statistical difference in MDA

AChE

and SOD levels between treatment group and normal group. Conclusion: Jiannao Bushen pils combined with GLT can effectively improve the memorial function of MCI patients

and its therapeutic mechanism may be associated with alleviating the damage of oxygen free radicals and depressing the activity of AChE.