Objective: To investigate the effect of Huangqi injection on oxidative stress and inflammatory response in patients with viral myocarditis. Method: One hundred and seventy-eight patients with viral myocarditis hospitalized in our cardiology department from May 2011 to December 2013 were selected. All cases were divided into combined group and conventional group according to random number table. Cases in conventional group were given with comprehensive western medicine treatment

while the cases in combined group were given with Huangqi injection intravenously on the basis of the conventional group. 12 h after hospitalization and two courses of treatment

the levels of superoxide dismutase (SOD)

malondialdehyde (MDA)

glutathione S-transferase (GST) and nitric oxide (NO)

as well as the levels of interleukin-6(IL-6)

interleukin-8(IL-8)

tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were detected. Result: The total effective rate of combined group was 88.8%

much higher than 71.9% of conventional group. The difference was statistically significant (P<0.05). After treatment

SOD and GST in the two groups were (123.6±12.4) U·mL-1 and (20.4±5.7) U·mL-1

which were increased than those before treatment

while MDA and NO were (3.3±0.2) μmol·L-1 and (68.4±10.9) mmol·L-1 which were reduced. The differences were statistically significant (P<0.05). After treatment

IL-6

IL-8

TNF-α and IFN-γ levels were higher than those before treatment in both groups (P<0.05). After treatment

IL-6

IL-8

TNF-α and IFN-γ levels were (43.5±20.3)

(16.8±1.9)

(8.9±1.5)

(273.8±79.6) ng·L-1respectively

lower than those in convention group. The differences were statistically significant (P<0.05). Conclusion: Huangqi injection could effectively improve the clinical treatment for viral myocarditis

reduce the effects of oxidative stress and inflammatory response on myocardial cells injury.