四逆汤中干姜与其他药味配伍后姜辣素成分的变化规律

蒋燕萍; 彭伟; 曹丽梅; 游宇; 高飞; 傅超美

doi:10.13422/j.cnki.syfjx.2015240001

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四逆汤中干姜与其他药味配伍后姜辣素成分的变化规律

药剂与炮制 | 更新时间：2024-09-23

- 四逆汤中干姜与其他药味配伍后姜辣素成分的变化规律
- Change Law of Gingerols from Zingiberis Rhizoma in Sini Tang Before and After Compatibility with Other Herbs
- 中国实验方剂学杂志 2015年21卷第24期页码：1-4
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81373987)
- DOI：10.13422/j.cnki.syfjx.2015240001
  中图分类号： R283.6
- 纸质出版日期：2015
- 稿件说明：
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蒋燕萍, 彭伟, 曹丽梅, 等. 四逆汤中干姜与其他药味配伍后姜辣素成分的变化规律[J]. 中国实验方剂学杂志, 2015,21(24):1-4.

JIANG Yan-ping, Peng Wei, CAO Li-mei, et al. Change Law of Gingerols from Zingiberis Rhizoma in Sini Tang Before and After Compatibility with Other Herbs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 1-4.
蒋燕萍, 彭伟, 曹丽梅, 等. 四逆汤中干姜与其他药味配伍后姜辣素成分的变化规律[J]. 中国实验方剂学杂志, 2015,21(24):1-4. DOI： 10.13422/j.cnki.syfjx.2015240001.

JIANG Yan-ping, Peng Wei, CAO Li-mei, et al. Change Law of Gingerols from Zingiberis Rhizoma in Sini Tang Before and After Compatibility with Other Herbs[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 1-4. DOI： 10.13422/j.cnki.syfjx.2015240001.

摘要

目的:探索四逆汤中干姜与其他药味配伍后

姜辣素成分6-姜辣素

8-姜辣素和6-姜烯酚含量的变化规律。方法:以四逆汤、干姜单煎液、干姜-附子合煎液、干姜-甘草合煎液为供试品

采用HPLC测定供试品中3种姜辣素成分的含量

流动相0.1%冰乙酸(A)-乙腈(B)梯度洗脱(0~30 min

60%~10%A;30~35 min

10%~60%A)

检测波长275 nm。结果:干姜配伍不同药味后

3种姜辣素成分含量均升高

依次为干姜-甘草合煎液>四逆汤>干姜-附子合煎液>干姜单煎液。结论:干姜配伍附子后干姜中姜辣素成分含量升高

可为干姜可助附子回阳救逆提供参考;干姜配伍甘草后干姜中姜辣素成分含量大幅度升高

为甘草配伍干姜提升温补阳气之力提供了一定实验数据;干姜与附子、甘草共同配伍后干姜中姜辣素成分含量明显升高

说明四逆汤方中3味药相互依托、相互制约以共奏回阳救逆之效

体现了四逆汤组方的科学内涵。

Abstract

Objective: To investigate change law of contents of gingerols(6-gingerol

8-gingerol and 6-shogaol) from Zingiberis Rhizoma in Sini Tang before and after compatibility with other herbs in this prescription. Method: Taking Sini Tang

single decoction of Zingiberis Rhizoma

Zingiberis Rhizoma-Aconiti Lateralis Radix Praeparata decoction and Zingiberis Rhizoma-Glycyrrhizae Radix et Rhizoma decoction as test samples

contents of these three gingerols in samples were measured by HPLC. Result: Contents of 6-gingerol

8-gingerol and 6-shogaol increased after Zingiberis Rhizoma compatibility with different medicines

sequence was Zingiberis Rhizoma-Glycyrrhizae Radix et Rhizoma decoction >Sini Tang >Zingiberis Rhizoma-Aconiti Lateralis Radix Praeparata decoction>single decoction of Zingiberis Rhizoma. Conclusion: Contents of gingerols increase after Zingiberis Rhizoma compatibility with Aconiti Lateralis Radix Praeparata

which provides scientific basis for Zingiberis Rhizoma enhancing efficacy of Aconiti Lateralis Radix Praeparata.Contents of gingerols increase sharply after Zingiberis Rhizoma compatibility with Glycyrrhizae Radix et Rhizoma

which provides a certain scientific data for Glycyrrhizae Radix et Rhizoma promoting Wenbu Yangqi effect of Zingiberis Rhizoma.Contents of gingerols increase obviously in Sini Tang

it indicates that these three medicines in Sini Tang are interplaying to play efficacy

which reflecting scientific connotation of formula establishment of Sini Tang.

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