根皮素固体分散体的制备和表征

韩雷; 马诗经; 江森; 张玉; 何燕; 杜志云; 张焜

doi:10.13422/j.cnki.syfjx.2015240010

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根皮素固体分散体的制备和表征

药剂与炮制 | 更新时间：2024-09-23

- 根皮素固体分散体的制备和表征
- Preparation and Characterization of Phloretin Solid Dispersions
- 中国实验方剂学杂志 2015年21卷第24期页码：10-13
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(21272043);广东省教育部产学研结合项目(2012B091000170)
- DOI：10.13422/j.cnki.syfjx.2015240010
  中图分类号： R283.6
- 纸质出版日期：2015
- 稿件说明：
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韩雷, 马诗经, 江森, 等. 根皮素固体分散体的制备和表征[J]. 中国实验方剂学杂志, 2015,21(24):10-13.

HAN Lei, MA Shi-jing, JIANG Sen, et al. Preparation and Characterization of Phloretin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 10-13.
韩雷, 马诗经, 江森, 等. 根皮素固体分散体的制备和表征[J]. 中国实验方剂学杂志, 2015,21(24):10-13. DOI： 10.13422/j.cnki.syfjx.2015240010.

HAN Lei, MA Shi-jing, JIANG Sen, et al. Preparation and Characterization of Phloretin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 10-13. DOI： 10.13422/j.cnki.syfjx.2015240010.

摘要

目的:将根皮素制备成固体分散体

以提高其水溶性

并对其进行物理性质表征

为根皮素的产业推广提供参考。方法:以聚维酮(PVP K-30)为载体材料

采用溶剂法制备根皮素固体分散体

考察其载药率与溶解度。利用差示扫描量热法(DSC)

X射线衍射法(XRD)

傅里叶红外光谱法(FT-IR)对根皮素固体分散体进行物性表征。结果:根皮素与PVP K-30的质量比为1:9时

根皮素固体分散体载药率95.99%

溶解度0.42 g·L-1

与根皮素对照品相比

溶解度提高了14倍。DSC和XRD分析结果显示根皮素可能以分子或无定形态均匀分散于PVP K-30中

FT-IR结果表明根皮素与PVP K-30之间可能以氢键形式缔合。结论:根皮素制成固体分散体后能够显著提高药物的溶解度。

Abstract

Objective: To prepare phloretin solid dispersions by improving solubility of phloretin in water and characterize physical properties of this preparation for providing a reference for industrial promotion of phloretin. Method: Taking povidone K-30(PVP K-30) as carrier material

drug-loading rate and solubility as indexes

phloretin solid dispersions were prepared by solvent method.Physical properties characterization of phloretin solid dispersions were analyzed by DSC

XRD and FT-IR. Result: When the mass ratio of phloretin to PVP K-30 was 1:9

drug-loading rate of phloretin solid dispersions was 95.99%;solubility of phloretin was 0.42 g·L-1

compared with reference substance of phloretin

solubility improved 14 times.Analysis result of DSC and XRD showed phloretin probably dispersed in PVP K-30 in the form of molecues or amorphous state.FT-IR result showed phloretin and PVP K-30 maybe associated in the form of hydrogen bond. Conclusion: After being prepared to solid dispersion

solubility of phloretin can significantly improve.

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