壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒的制备及其pH响应性释药性能考察

唐涛; 臧巧真; 龙凯花; 王春柳; 李晔

doi:10.13422/j.cnki.syfjx.2015240014

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壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒的制备及其pH响应性释药性能考察

药剂与炮制 | 更新时间：2024-09-23

- 壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒的制备及其pH响应性释药性能考察
- Preparation and pH Responsive Release of Andrographolide-loaded Mesoporous Silica Nanoparticles Modified by Chitosan
- 中国实验方剂学杂志 2015年21卷第24期页码：14-17
- 作者机构：
- 作者简介：
- 基金信息：
  
  陕西省重点科技创新团队计划项目(2012KCT-18)
- DOI：10.13422/j.cnki.syfjx.2015240014
  中图分类号： R283.6
- 纸质出版日期：2015
- 稿件说明：
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唐涛, 臧巧真, 龙凯花, 等. 壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒的制备及其pH响应性释药性能考察[J]. 中国实验方剂学杂志, 2015,21(24):14-17.

TANG Tao, ZANG Qiao-zhen, LONG Kai-hua, et al. Preparation and pH Responsive Release of Andrographolide-loaded Mesoporous Silica Nanoparticles Modified by Chitosan[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 14-17.
唐涛, 臧巧真, 龙凯花, 等. 壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒的制备及其pH响应性释药性能考察[J]. 中国实验方剂学杂志, 2015,21(24):14-17. DOI： 10.13422/j.cnki.syfjx.2015240014.

TANG Tao, ZANG Qiao-zhen, LONG Kai-hua, et al. Preparation and pH Responsive Release of Andrographolide-loaded Mesoporous Silica Nanoparticles Modified by Chitosan[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 14-17. DOI： 10.13422/j.cnki.syfjx.2015240014.

摘要

目的:制备壳聚糖修饰的载穿心莲内酯介孔二氧化硅纳米粒(CS/Ap-MSN)

对其进行体外质量评价及pH响应性释药性能考察。方法:根据改良经典stober法一步合成了氨基修饰的介孔二氧化硅纳米粒(NH2-MSN)

利用壳聚糖进行偶联修饰

表征其形貌及结构

通过体外释放试验考察CS/Ap-MSN在不同pH条件下的响应性释药性能。结果:CS/Ap-MSN的平均粒径(178.0±3.2) nm

多分散指数0.378±0.117

Zeta电位(34.04±0.22) mV

载药量和包封率分别为(27.8±1.7)%

(63.6±3.2)%

壳聚糖的修饰量6.3%。CS/Ap-MSN在pH 5.0的释放条件下

8 d累计释药量达53.3%;pH 7.4的释放条件下

8 d的累计释药量23.4%。结论:CS/Ap-MSN的体外释药具有pH响应性

累积释放量随pH减小而增大

且具有一定的缓释性能。

Abstract

Objective: To prepare andrographolide-loaded mesoporous silica nanoparticles modified by chitosan(CS/Ap-MSN) and investigate its quality and pH-responsive release behavior. Method: Mesoporous silica nanoparticles modified by amino(NH2-MSN) were synthesized by modified stober method in one step.Chitosan was covalently attached to exterior surface of NH2-MSN

morphology and structure of this product were characterized.In viro drug release behavior of CS/Ap-MSN in different pH was investigated. Result: Mean particle size of CS/Ap-MSN was(178.0±3.2) nm

PDI was 0.378±0.117 and Zeta potential was(34.04±0.22) mV

drug loading efficiency and encapsulation efficiency were(27.8±1.7)% and(63.6±3.2)%

respectively;modification amount of chitosan was 6.3%.Cumulative release amount of CS/Ap-MSN reached to 53.3% at pH of 5.0 after 8 days;while cumulative release amount of CS/Ap-MSN reached to 23.4% at pH of 7.4 after 8 days. Conclusion: In vitro release behavior of CS/Ap-MSN shows pH-responsive characteristic and sustained-release characteristic

cumulative release amount increases with decreasing of pH.

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