Objective: To investigate tissue distribution of auraptene in rats. Method: Rat intragastric administration method was used.The content of auraptene in tissue sample was calculated after determining four time points with intragastric administration and taking tissue samples successively by establish a standard curve for drugs in various tissues.Meanwhile

two sample quality control(QC) sample with high

medium and low concentrations were done for judging reliability of results of this batch of samples.Data were analyzed by Analyst 1.6 software. Result: With gastric administration by 100 mg·kg-1

auraptene was rapidly distributed in different tissues including heart

liver

spleen

lung

kidney

stomach

small intestine and muscle after 30 min.The concentration of auraptene in small intestine significantly decreased by 120 min

while drug concentrations in fat and blood mainly increased.The concentration of drug for other issues beside brain by 6 h were dropped greatly and then drug concentration of all main issues decreased significantly at 8 h. Conclusion: Auraptene soft capsule can be rapidly distributed in main tissues of rats after gastric administration

drug concentration in gastrointestinal tract is always high

its concentrations in liver and lung are higher than other tissues.In addition

the concentration of auraptene in brain tissue remains at a high level

which may be related to active targeting of auraptene soft capsule on senile dementia.