Objective: To observe the clinical efficacy of Huazhi Rougan granule in treating damp-heat accumulation type non-alcoholic fatty liver disease(NAFLD) and its influence on serum β-arrestin and osteocalcin levels. Method: One hundred and eighty NAFLD patients were randomly divided into control group(90 cases) and treatment group(90 cases). Both groups received basic treatment without drug referring to Clinical Practice Guideline for Non-alcoholic Fatty Liver Disease. Patients of control group also received compound methionine and choline bitartrate tablets(3 tablets/time

tid). Patients in treatment group also received Huazhi Rougan granule(1 dose/d

tid

and resting for 1 d every 6 ds). Course of treatment was 12 weeks for both groups. Alanine aminotransferase(ALT)

aspartate transaminase(AST)

total cholesterol(TC)

and triglyceride(TG) levels were detected between both groups. Symptom scores of traditional Chinese medicine(TCM)

body mass index(BMI)

and waist-hip ratio(WHR) were observed between two groups. Serum β-arrestin-1

β-arrestin-2

and OCN levels were measured. Result: The total efficacy of treatment group was 92.22%

higher than 77.77% in control group

with statistical difference(P<0.05). Compared with control group

ALT

AST

TC

and TG levels in treatment group were significantly decreased after treatment(P<0.01). TCM scores and BMI of treatment group were significantly lower than those in control group after treatment

with statistically significant difference(P<0.01). After treatment

serum β-arrestin-1 level in treatment group was significantly lower than that in control group

and OCN was higher in treatment group

with statistical difference(P<0.01)

however β-arrestin-2 level for two groups was not obviously changed before and after treatment. Conclusion: Huazhi Rougan granule could improve clinical signs in treating damp-heat accumulation type NAFLD

protect liver function

promote blood lipid back to normal

decrease serum β-arrestin-1 level and increase OCN level.